Genetics of Circadian Rhythms.
Sleep Med Clin
; 10(4): 413-21, 2015 Dec.
Article
in En
| MEDLINE
| ID: mdl-26568119
ABSTRACT
Nearly all organisms exhibit time-dependent behavior and physiology across a 24-hour day known as circadian rhythms. These outputs are manifestations of endogenous cyclic gene expression patterns driven by the activity of a core transcription/translation feedback loop. Cyclic gene expression determines highly tissue-specific functional activity regulating such processes as metabolic state, endocrine activity, and neural excitability. Entrainment of these cellular clocks is achieved through exogenous daily inputs, such as light and food. Dysregulation of the transcription/translation feedback loop has been shown to result in a wide range of disorders and diseases driving increased interest in circadian therapies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Circadian Rhythm
/
Circadian Clocks
Limits:
Animals
/
Humans
Language:
En
Journal:
Sleep Med Clin
Year:
2015
Document type:
Article
Affiliation country:
United States