APC, adenomatous polyposis coli; BA, bile acids; BSH, bile salt hydrolases; Bile acids; CA, cholic acid; CDCA, chenodeoxycholic acid; COX-2, cyclooxygenase-2; CRC, colorectal cancer; CYP27A1, sterol-27-hydroxylase; CYP7A1, cholesterol 7α-hydroxylase; CYP8B1, sterol 12α-hydroxylase; DCA, deoxycholic acid; EGFR, epidermal growth factor receptor; FAP, familial adenomatous polyposis; FGF15/19, fibroblast growth factor 15/19; FXR, farnesoid X receptor; GABA, γ-aminobutyric acid; GPCR, G-protein coupled receptors; Gut microbiome; HMP, Human Microbiome Project; HSDH, hydroxysteroid dehydrogenase; LCA, lithocholic acid; LOX, lipooxygenase; MetaHIT, Metagenomics of the Human Intestinal Tract; Metabolite; NSAIDs, non-steroidal anti-inflammatory drugs; PKC, protein kinase C; PSC, primary sclerosing cholangitis; PXR, pregnane X receptor; Sterolbiome; Therapeutic agent; UDCA, ursodeoxycholic acid; VDR, vitamin D receptor