A review of HER2-targeted therapy in breast and ovarian cancer: lessons from antiquity - CLEOPATRA and PENELOPE.

Hodeib, Melissa; Serna-Gallegos, Tasha; Tewari, Krishnansu S

Hodeib, Melissa; Serna-Gallegos, Tasha; Tewari, Krishnansu S.

Affiliation

Hodeib M; Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of California, Irvine-Medical Center, Orange, CA, USA.
Serna-Gallegos T; Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of California, Irvine-Medical Center, Orange, CA, USA.
Tewari KS; Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of California, Irvine-Medical Center, Orange, CA, USA.

Future Oncol ; 11(23): 3113-31, 2015.

Article in En | MEDLINE | ID: mdl-26597460

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Breast Neoplasms/drug therapy; Ovarian Neoplasms/drug therapy; Receptor, ErbB-2/antagonists & inhibitors; Antineoplastic Agents/administration & dosage; Breast Neoplasms/genetics; Breast Neoplasms/mortality; Breast Neoplasms/pathology; Carcinoma, Ovarian Epithelial; Clinical Trials, Phase III as Topic; Drug Discovery; Female; Gene Expression Regulation, Neoplastic/drug effects; Humans; Molecular Targeted Therapy; Neoplasms, Glandular and Epithelial/drug therapy; Neoplasms, Glandular and Epithelial/metabolism; Neoplasms, Glandular and Epithelial/pathology; Oncogene Proteins/genetics; Oncogene Proteins/metabolism; Ovarian Neoplasms/genetics; Ovarian Neoplasms/metabolism; Ovarian Neoplasms/mortality; Ovarian Neoplasms/pathology; Randomized Controlled Trials as Topic; Receptor, ErbB-2/genetics; Treatment Outcome

Key words

CLEOPATRA; HER2/neu; PENELOPE; T-DM1; breast cancer; lapatinib; ovarian cancer; pertuzumab; trastuzumab

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Breast Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Receptor, ErbB-2 Type of study: Clinical_trials Limits: Female / Humans Language: En Journal: Future Oncol Year: 2015 Document type: Article Affiliation country: United States Country of publication: United kingdom

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