Endotoxemia Engages the RhoA Kinase Pathway to Impair Cardiac Function By Altering Cytoskeleton, Mitochondrial Fission, and Autophagy.

Preau, Sebastien; Delguste, Florian; Yu, Yichi; Remy-Jouet, Isabelle; Richard, Vincent; Saulnier, Fabienne; Boulanger, Eric; Neviere, Remi

Preau, Sebastien; Delguste, Florian; Yu, Yichi; Remy-Jouet, Isabelle; Richard, Vincent; Saulnier, Fabienne; Boulanger, Eric; Neviere, Remi.

Affiliation

Preau S; 1 Department of Physiology, School of Medicine , Lille, France .
Delguste F; 2 INSERM U995/Team "Glycation: from inflammation to aging, " Lille University , France .
Yu Y; 3 Critical Care Medicine , CHRU Lille, Lille, France .
Remy-Jouet I; 1 Department of Physiology, School of Medicine , Lille, France .
Richard V; 2 INSERM U995/Team "Glycation: from inflammation to aging, " Lille University , France .
Saulnier F; 2 INSERM U995/Team "Glycation: from inflammation to aging, " Lille University , France .
Boulanger E; 4 School of Medicine, Shanghai Jiao Tong University , Shanghai, China .
Neviere R; 5 INSERM U1096 Institute for Research and Innovation in Biomedicine, University of Rouen , France .

Antioxid Redox Signal ; 24(10): 529-42, 2016 Apr 01.

Article in En | MEDLINE | ID: mdl-26602979

Subject(s)

Autophagy; Endotoxemia/metabolism; Heart/physiopathology; Mitochondrial Dynamics; Myocardium/metabolism; Signal Transduction; rho-Associated Kinases/metabolism; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology; Actin Depolymerizing Factors/genetics; Actin Depolymerizing Factors/metabolism; Animals; Autophagy/drug effects; Calcium Channel Blockers/pharmacology; Cytoskeleton/metabolism; Cytoskeleton/ultrastructure; Gene Expression; Lipopolysaccharides/adverse effects; Male; Mice; Mitochondrial Dynamics/drug effects; Myocardial Contraction/drug effects; Myocarditis/etiology; Myocarditis/metabolism; Myocarditis/pathology; Myocarditis/physiopathology; Myocardium/ultrastructure; Oxidative Stress; Reactive Oxygen Species/metabolism; Sarcomeres/metabolism; Sarcomeres/ultrastructure

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Signal Transduction / Endotoxemia / Rho-Associated Kinases / Mitochondrial Dynamics / Heart / Myocardium Type of study: Etiology_studies Limits: Animals Language: En Journal: Antioxid Redox Signal Journal subject: METABOLISMO Year: 2016 Document type: Article Affiliation country: France

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