Alpinetin inhibits lung cancer progression and elevates sensitization drug-resistant lung cancer cells to cis-diammined dichloridoplatium.

Wu, Lin; Yang, Wei; Zhang, Su-ning; Lu, Ji-bin

Wu, Lin; Yang, Wei; Zhang, Su-ning; Lu, Ji-bin.

Affiliation

Wu L; Department of Thoracic Surgery, Sheng Jing Hospital of China Medical University, Shenyang, People's Republic of China.
Yang W; Department of Thoracic Surgery, Sheng Jing Hospital of China Medical University, Shenyang, People's Republic of China.
Zhang SN; Department of Thoracic Surgery, Sheng Jing Hospital of China Medical University, Shenyang, People's Republic of China.
Lu JB; Department of Thoracic Surgery, Sheng Jing Hospital of China Medical University, Shenyang, People's Republic of China.

Drug Des Devel Ther ; 9: 6119-27, 2015.

Article in En | MEDLINE | ID: mdl-26604699

Subject(s)

Antineoplastic Agents/pharmacology; Cisplatin/pharmacology; Disease Progression; Drug Resistance, Neoplasm/drug effects; Flavanones/pharmacology; Lung Neoplasms/drug therapy; Apoptosis/drug effects; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms/metabolism; Lung Neoplasms/pathology; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/drug effects; Structure-Activity Relationship; Tumor Cells, Cultured

Key words

PI3K/Akt; alpinetin; cell proliferation and apoptosis; drug resistance reversal; lung cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cisplatin / Disease Progression / Drug Resistance, Neoplasm / Flavanones / Lung Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Drug Des Devel Ther Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2015 Document type: Article Country of publication: New Zealand

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