Your browser doesn't support javascript.
loading
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.
Brennand, Kristen J; Marchetto, M Carol; Benvenisty, Nissim; Brüstle, Oliver; Ebert, Allison; Izpisua Belmonte, Juan Carlos; Kaykas, Ajamete; Lancaster, Madeline A; Livesey, Frederick J; McConnell, Michael J; McKay, Ronald D; Morrow, Eric M; Muotri, Alysson R; Panchision, David M; Rubin, Lee L; Sawa, Akira; Soldner, Frank; Song, Hongjun; Studer, Lorenz; Temple, Sally; Vaccarino, Flora M; Wu, Jun; Vanderhaeghen, Pierre; Gage, Fred H; Jaenisch, Rudolf.
Affiliation
  • Brennand KJ; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
  • Marchetto MC; Laboratory of Genetics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, San Diego, CA 92037, USA.
  • Benvenisty N; Department of Genetics, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
  • Brüstle O; Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn, Bonn 53127, Germany.
  • Ebert A; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
  • Izpisua Belmonte JC; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, San Diego, CA 92037, USA.
  • Kaykas A; Department of Neurobiology, Novartis Institute for BioMedical Research, Inc., 100 Technology Square, Cambridge, MA 02139, USA.
  • Lancaster MA; Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
  • Livesey FJ; Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
  • McConnell MJ; Department of Biochemistry and Molecular Genetics, Center for Brain Immunology and Glia, University of Virginia School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA.
  • McKay RD; Brain Development, Lieber Institute for Brain Development, 855 North Wolfe Street, Baltimore, MD 21205, USA.
  • Morrow EM; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship Street, Providence, RI 02912, USA.
  • Muotri AR; Department of Cellular & Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA.
  • Panchision DM; Developmental Neurobiology Program, National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA.
  • Rubin LL; Department of Stem Cell and Regenerative Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
  • Sawa A; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA.
  • Soldner F; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
  • Song H; Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA.
  • Studer L; Stem Cell and Tumor Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 256, New York, NY 10021, USA.
  • Temple S; Neural Stem Cell Institute, One Discovery Drive, Rensselaer, NY 12144, USA.
  • Vaccarino FM; Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA.
  • Wu J; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, San Diego, CA 92037, USA.
  • Vanderhaeghen P; Institute of Interdisciplinary Research (IRIBHM), University of Brussels ULB, 808, Route de Lennik, 1070 Brussels, Belgium.
  • Gage FH; Laboratory of Genetics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, San Diego, CA 92037, USA. Electronic address: fgage@salk.edu.
  • Jaenisch R; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. Electronic address: jaenisch@wi.mit.edu.
Stem Cell Reports ; 5(6): 933-945, 2015 Dec 08.
Article in En | MEDLINE | ID: mdl-26610635
ABSTRACT
As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Brain Diseases / Neurogenesis / Induced Pluripotent Stem Cells Type of study: Prognostic_studies Limits: Humans Language: En Journal: Stem Cell Reports Year: 2015 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Brain Diseases / Neurogenesis / Induced Pluripotent Stem Cells Type of study: Prognostic_studies Limits: Humans Language: En Journal: Stem Cell Reports Year: 2015 Document type: Article Affiliation country: United States