Retrospective survey to evaluate the safety and efficacy of Japanese botulinum antitoxin therapy in Japan.
Toxicon
; 110: 12-8, 2016 Feb.
Article
in En
| MEDLINE
| ID: mdl-26615088
Japanese botulinum antitoxins have been used for more than 50 years; however, their safety and therapeutic efficacy are not clear. In order to analyze the available data on botulinum antitoxin therapy in Japan, we surveyed published reports about botulism cases in which botulinum antitoxins were used, and retrospectively analyzed the safety and efficacy of the therapy. A total of 134 patients administered botulinum antitoxins were identified from published reports. Two cases of side effects (1.5%) were detected after antitoxin administration, both not fatal. The fatality rate was 9.4%, and more than 70% of the patients showed improvement in their symptoms and better clinical conditions than those not treated with antitoxins. These data suggest that the therapy with Japanese antitoxins is safe and highly effective.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Botulism
/
Botulinum Antitoxin
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Toxicon
Year:
2016
Document type:
Article
Country of publication:
United kingdom