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LncRNA NONRATT021972 involved the pathophysiologic processes mediated by P2X7 receptors in stellate ganglia after myocardial ischemic injury.
Zou, Lifang; Tu, Guihua; Xie, Wei; Wen, Shiyao; Xie, Qiuyu; Liu, Shuangmei; Li, Guilin; Gao, Yun; Xu, Hong; Wang, Shouyu; Xue, Yun; Wu, Bing; Lv, Qiulan; Ying, Mofeng; Zhang, Xi; Liang, Shangdong.
Affiliation
  • Zou L; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Tu G; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Xie W; Undergraduate student of grade 2012, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Wen S; Undergraduate student of grade 2012, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Xie Q; Undergraduate student of grade 2012, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Liu S; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Li G; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Gao Y; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Xu H; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Wang S; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Xue Y; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Wu B; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Lv Q; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Ying M; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Zhang X; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Liang S; Department of Physiology, Medical School of Nanchang University, Nanchang, 330006, People's Republic of China. liangsd@hotmail.com.
Purinergic Signal ; 12(1): 127-37, 2016 Mar.
Article in En | MEDLINE | ID: mdl-26630943
ABSTRACT
Adenosine triphosphate (ATP) acts on P2X receptors to initiate signal transmission. P2X7 receptors play a role in the pathophysiological process of myocardial ischemic injury. Long noncoding RNAs (lncRNAs) participate in numerous biological functions independent of protein translation. LncRNAs are implicated in nervous system diseases. This study investigated the effects of NONRATT021972 small interference RNA (siRNA) on the pathophysiologic processes mediated by P2X7 receptors in stellate ganglia (SG) after myocardial ischemic injury. Our results demonstrated that the expression of NONRATT021972 in SG was significantly higher in the myocardial ischemic (MI) group than in the control group. Treatment of MI rats with NONRATT021972 siRNA, the P2X7 antagonist brilliant blue G (BBG), or P2X7 siRNA improved the histology of injured ischemic cardiac tissues and decreased the elevated concentrations of serum myocardial enzymes, creatine kinase (CK), CK isoform MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) compared to the MI rats. NONRATT021972 siRNA, BBG, or P2X7 siRNA treatment in MI rats decreased the expression levels of P2X7 immunoreactivity, P2X7 messenger RNA (mRNA), and P2X7 protein, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) in the SG compared to MI rats. NONRATT021972 siRNA treatment prevented the pathophysiologic processes mediated by P2X7 receptors in the SG after myocardial ischemic injury.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stellate Ganglion / Myocardial Ischemia / Receptors, Purinergic P2X7 / RNA, Long Noncoding Limits: Animals Language: En Journal: Purinergic Signal Year: 2016 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stellate Ganglion / Myocardial Ischemia / Receptors, Purinergic P2X7 / RNA, Long Noncoding Limits: Animals Language: En Journal: Purinergic Signal Year: 2016 Document type: Article