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Stimulation of adenosine A2A receptors reduces intracellular cholesterol accumulation and rescues mitochondrial abnormalities in human neural cell models of Niemann-Pick C1.
Ferrante, A; De Nuccio, C; Pepponi, R; Visentin, S; Martire, A; Bernardo, A; Minghetti, L; Popoli, P.
Affiliation
  • Ferrante A; Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, 00161, Rome, Italy. Electronic address: antonella.ferrante@iss.it.
  • De Nuccio C; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, 00161, Rome, Italy.
  • Pepponi R; Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, 00161, Rome, Italy.
  • Visentin S; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, 00161, Rome, Italy.
  • Martire A; Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, 00161, Rome, Italy.
  • Bernardo A; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, 00161, Rome, Italy.
  • Minghetti L; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, 00161, Rome, Italy.
  • Popoli P; Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, 00161, Rome, Italy.
Neuropharmacology ; 103: 155-62, 2016 Apr.
Article in En | MEDLINE | ID: mdl-26631535
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholesterol / Receptor, Adenosine A2A / Niemann-Pick Disease, Type C / Adenosine A2 Receptor Agonists / Mitochondria / Neurons Type of study: Prognostic_studies Limits: Humans Language: En Journal: Neuropharmacology Year: 2016 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholesterol / Receptor, Adenosine A2A / Niemann-Pick Disease, Type C / Adenosine A2 Receptor Agonists / Mitochondria / Neurons Type of study: Prognostic_studies Limits: Humans Language: En Journal: Neuropharmacology Year: 2016 Document type: Article