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Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.
Duquette, Mark; Sadow, Peter M; Husain, Amjad; Sims, Jennifer N; Antonello, Zeus A; Fischer, Andrew H; Song, Chen; Castellanos-Rizaldos, Elena; Makrigiorgos, G Mike; Kurebayashi, Junichi; Nose, Vania; Van Hummelen, Paul; Bronson, Roderick T; Vinco, Michelle; Giordano, Thomas J; Dias-Santagata, Dora; Pandolfi, Pier Paolo; Nucera, Carmelo.
Affiliation
  • Duquette M; Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Sadow PM; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, MA, Boston, USA.
  • Husain A; Department of Pathology, Center for Vascular Biology Research (CVBR), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Sims JN; Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Antonello ZA; Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Fischer AH; Department of Pathology, University of Massachusetts, Worcester, MA, USA.
  • Song C; Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Castellanos-Rizaldos E; Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Makrigiorgos GM; Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Kurebayashi J; Department of Breast and Thyroid Surgery, Kawasaki Medical School, Kurashiki, Japan.
  • Nose V; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, MA, Boston, USA.
  • Van Hummelen P; Center for Cancer Genome Discovery (CCGD), Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Bronson RT; Rodent Histopathology Unit, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.
  • Vinco M; Department of Pathology, University of Michigan, Ann Harbor, MI, USA.
  • Giordano TJ; Department of Pathology, University of Michigan, Ann Harbor, MI, USA.
  • Dias-Santagata D; Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Pandolfi PP; Division of Cancer Genetics, Cancer Research Institute (CRI), Department of Medicine and Department of Pathology, Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Nucera C; Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Oncotarget ; 6(40): 42445-67, 2015 Dec 15.
Article in En | MEDLINE | ID: mdl-26636651
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Thyroid Neoplasms / Carcinoma / Gene Dosage / Drug Resistance, Neoplasm / Genes, p16 / Myeloid Cell Leukemia Sequence 1 Protein / Indoles / Antineoplastic Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Oncotarget Year: 2015 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Thyroid Neoplasms / Carcinoma / Gene Dosage / Drug Resistance, Neoplasm / Genes, p16 / Myeloid Cell Leukemia Sequence 1 Protein / Indoles / Antineoplastic Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Oncotarget Year: 2015 Document type: Article Affiliation country: United States