Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats.
J Vet Med Sci
; 78(3): 499-503, 2016 Mar.
Article
in En
| MEDLINE
| ID: mdl-26638897
The gene expression levels of heparanase, matrix metalloproteinase 2 (MMP2) and MMP9 were examined in ventricles after treatment with monocrotaline (MCT) to induce cardiac hypertrophy in rats. Rats received a single intraperitoneal injection of MCT (60 mg/kg) or saline. Twenty-five days after the injection, the right ventricle and lung wet weights were increased in MCT-treated rats compared with the control. Histological analysis revealed cardiomyocyte hypertrophy in the right ventricle of MCT-treated rats. Northern blot hybridization showed that heparanase and MMP2 expression increased significantly in the right and left ventricles of MCT-treated rats, whereas MMP9 was not induced. These findings indicate that heparanase and MMP2 might play an important role in the development of MCT-induced cardiac hypertrophy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hypertrophy, Right Ventricular
/
Glucuronidase
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Vet Med Sci
Journal subject:
MEDICINA VETERINARIA
Year:
2016
Document type:
Article
Affiliation country:
Japan
Country of publication:
Japan