Downstream modulation of extrinsic apoptotic pathway in streptozotocin-induced Alzheimer's dementia in rats: Erythropoietin versus curcumin.

Samy, Doaa M; Ismail, Cherine A; Nassra, Rasha A; Zeitoun, Teshreen M; Nomair, Azhar M

Samy, Doaa M; Ismail, Cherine A; Nassra, Rasha A; Zeitoun, Teshreen M; Nomair, Azhar M.

Affiliation

Samy DM; Department of Medical Physiology, Faculty of Medicine, Al-Moassat Hospital, University of Alexandria, Egypt. Electronic address: doaa.abdelhady@alexmed.edu.eg.
Ismail CA; Department of Clinical Pharmacology, Faculty of Medicine, Al-Moassat Hospital, University of Alexandria, Egypt. Electronic address: cherine.ismail@alexmed.edu.eg.
Nassra RA; Department of Medical Biochemistry, Faculty of Medicine, Al-Moassat Hospital, University of Alexandria, Egypt. Electronic address: rasha.nassra@alexmed.edu.eg.
Zeitoun TM; Department of Histology and Cell Biology, Faculty of Medicine, Al-Moassat Hospital, University of Alexandria, Egypt. Electronic address: elsaayghs@gmail.com.
Nomair AM; Department of Chemical Pathology, Medical Research Institute, University of Alexandria, Egypt. Electronic address: azhar.mohmd@yahoo.com.

Eur J Pharmacol ; 770: 52-60, 2016 Jan 05.

Article in En | MEDLINE | ID: mdl-26638997

Subject(s)

Alzheimer Disease/drug therapy; Alzheimer Disease/pathology; Apoptosis/drug effects; Curcumin/pharmacology; Erythropoietin/pharmacology; Signal Transduction/drug effects; Streptozocin/pharmacology; Alzheimer Disease/chemically induced; Alzheimer Disease/physiopathology; Amyloid beta-Peptides/metabolism; Animals; Antioxidants/pharmacology; Antioxidants/therapeutic use; Behavior, Animal/drug effects; Curcumin/therapeutic use; Erythropoietin/therapeutic use; Hematocrit; Hippocampus/drug effects; Hippocampus/metabolism; Hippocampus/pathology; Hippocampus/physiopathology; Male; Oxidative Stress/drug effects; Rats; Rats, Wistar; Retention, Psychology/drug effects; Spatial Learning/drug effects

Key words

Alzheimer's; Beta-amyloid 40 (PubChem CID: 57339250); Beta-amyloid 42 (PubChem CID: 57339251); Beta-amyloid peptides; Curcumin; Curcumin (PubChem CID: 969516); Erythropoietin; Extrinsic apoptosis; Malondialdehyde (PubChem CID: 10964); Reduced glutathione (PubChem CID: 7048684); Streptozotocin; Streptozotocin (PubChem CID: 29327)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Erythropoietin / Apoptosis / Streptozocin / Curcumin / Alzheimer Disease Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2016 Document type: Article Country of publication: Netherlands

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