Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia.

Byrd, John C; Harrington, Bonnie; O'Brien, Susan; Jones, Jeffrey A; Schuh, Anna; Devereux, Steve; Chaves, Jorge; Wierda, William G; Awan, Farrukh T; Brown, Jennifer R; Hillmen, Peter; Stephens, Deborah M; Ghia, Paolo; Barrientos, Jacqueline C; Pagel, John M; Woyach, Jennifer; Johnson, Dave; Huang, Jane; Wang, Xiaolin; Kaptein, Allard; Lannutti, Brian J; Covey, Todd; Fardis, Maria; McGreivy, Jesse; Hamdy, Ahmed; Rothbaum, Wayne; Izumi, Raquel; Diacovo, Thomas G; Johnson, Amy J; Furman, Richard R

Byrd, John C; Harrington, Bonnie; O'Brien, Susan; Jones, Jeffrey A; Schuh, Anna; Devereux, Steve; Chaves, Jorge; Wierda, William G; Awan, Farrukh T; Brown, Jennifer R; Hillmen, Peter; Stephens, Deborah M; Ghia, Paolo; Barrientos, Jacqueline C; Pagel, John M; Woyach, Jennifer; Johnson, Dave; Huang, Jane; Wang, Xiaolin; Kaptein, Allard; Lannutti, Brian J; Covey, Todd; Fardis, Maria; McGreivy, Jesse; Hamdy, Ahmed; Rothbaum, Wayne; Izumi, Raquel; Diacovo, Thomas G; Johnson, Amy J; Furman, Richard R.

Affiliation

Byrd JC; From the Division of Hematology, Department of Internal Medicine, Ohio State University (J.C. Byrd, J.A.J., F.T.A., J.W., A.J.J.), and the Department of Veterinary Biosciences, College of Veterinary Medicine (B.H.) - both in Columbus; UC Irvine Health Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange (S.O.); University of Oxford, Oxford (A.S.), NHS Foundation Trust, King's College Hospital, London (S.D.), and the Department of Haematology, St. James's University H

N Engl J Med ; 374(4): 323-32, 2016 Jan 28.

Article in En | MEDLINE | ID: mdl-26641137

Subject(s)

Antineoplastic Agents/administration & dosage; Benzamides/administration & dosage; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyrazines/administration & dosage; Administration, Oral; Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Agents/adverse effects; Antineoplastic Agents/pharmacokinetics; Benzamides/adverse effects; Benzamides/pharmacokinetics; Chromosome Deletion; Diarrhea/chemically induced; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Headache/chemically induced; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/genetics; Male; Middle Aged; Protein Kinase Inhibitors/administration & dosage; Protein Kinase Inhibitors/adverse effects; Protein Kinase Inhibitors/pharmacokinetics; Pyrazines/adverse effects; Pyrazines/pharmacokinetics; Recurrence

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Benzamides / Protein-Tyrosine Kinases / Leukemia, Lymphocytic, Chronic, B-Cell / Antineoplastic Agents Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: N Engl J Med Year: 2016 Document type: Article Country of publication: United States

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