A novel cotton fabric with anti-bacterial and drug delivery properties using SBA-15-NH2/polysiloxane hybrid containing tetracycline.
Mater Sci Eng C Mater Biol Appl
; 59: 429-437, 2016 Feb.
Article
in En
| MEDLINE
| ID: mdl-26652393
ABSTRACT
Here, mesoporous silica particles containing tetracycline were loaded on cotton fabric for possible application on the infected human skin. Amino functionalized mesoporous silica, SBA-15-NH2, was chosen as a safe drug carrier loaded with tetracycline via post impregnation method. Diverse content of the drug loaded silica particles were then attached on the cotton fabric surface using polysiloxane reactive softener as a soft and safe fixing agent. UV-Vis spectroscopy was used to study the drug delivery properties of the mesoporous silica on the treated cotton fabrics. The treated fabric with long drug release properties was selected as the optimized sample. Further analysis was carried out on this sample including anti-bacterial, water contact angle, bending length, mineral content and washing durability. Also, SEM images, EDX patterns, X-Ray spectra and thermal behavior of the optimum sample were studied. The optimized treated sample indicated the gradual release profile of tetracycline in PBS buffer media within 48h along with excellent anti-bacterial efficiency as a good feature for biological application.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Siloxanes
/
Staphylococcus aureus
/
Tetracycline
/
Drug Delivery Systems
/
Silicon Dioxide
/
Cotton Fiber
/
Escherichia coli
Limits:
Humans
Language:
En
Journal:
Mater Sci Eng C Mater Biol Appl
Year:
2016
Document type:
Article
Affiliation country:
Iran
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS