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A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys.
Smith, Eric J; Olson, Kara; Haber, Lauric J; Varghese, Bindu; Duramad, Paurene; Tustian, Andrew D; Oyejide, Adelekan; Kirshner, Jessica R; Canova, Lauren; Menon, Jayanthi; Principio, Jennifer; MacDonald, Douglas; Kantrowitz, Joel; Papadopoulos, Nicholas; Stahl, Neil; Yancopoulos, George D; Thurston, Gavin; Davis, Samuel.
Affiliation
  • Smith EJ; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Olson K; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Haber LJ; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Varghese B; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Duramad P; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Tustian AD; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Oyejide A; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Kirshner JR; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Canova L; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Menon J; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Principio J; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • MacDonald D; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Kantrowitz J; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Papadopoulos N; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Stahl N; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Yancopoulos GD; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Thurston G; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Davis S; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
Sci Rep ; 5: 17943, 2015 Dec 11.
Article in En | MEDLINE | ID: mdl-26659273
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / T-Lymphocytes / Antibodies, Bispecific / Cytotoxicity, Immunologic / Antibody-Dependent Cell Cytotoxicity / Neoplasms Limits: Animals Language: En Journal: Sci Rep Year: 2015 Document type: Article Country of publication: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / T-Lymphocytes / Antibodies, Bispecific / Cytotoxicity, Immunologic / Antibody-Dependent Cell Cytotoxicity / Neoplasms Limits: Animals Language: En Journal: Sci Rep Year: 2015 Document type: Article Country of publication: United kingdom