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Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.
Chekler, Eugene L Piatnitski; Pellegrino, Jessica A; Lanz, Thomas A; Denny, R Aldrin; Flick, Andrew C; Coe, Jotham; Langille, Jonathan; Basak, Arindrajit; Liu, Shenping; Stock, Ingrid A; Sahasrabudhe, Parag; Bonin, Paul D; Lee, Kevin; Pletcher, Mathew T; Jones, Lyn H.
Affiliation
  • Chekler EL; Worldwide Medicinal Chemistry, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.
  • Pellegrino JA; The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
  • Lanz TA; Neuroscience and Pain Research Unit, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.
  • Denny RA; Worldwide Medicinal Chemistry, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.
  • Flick AC; Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
  • Coe J; Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
  • Langille J; Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
  • Basak A; Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
  • Liu S; Structural Biology and Biophysics, Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
  • Stock IA; Primary Pharmacology Group, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
  • Sahasrabudhe P; Structural Biology and Biophysics, Worldwide Medicinal Chemistry, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
  • Bonin PD; Primary Pharmacology Group, Pfizer, Eastern Point Road, Groton, CT 06340, USA.
  • Lee K; Rare Disease Research Unit, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.
  • Pletcher MT; Rare Disease Research Unit, Pfizer, 610 Main Street, Cambridge, MA 02139, USA.
  • Jones LH; Worldwide Medicinal Chemistry, Pfizer, 610 Main Street, Cambridge, MA 02139, USA. Electronic address: lyn.jones@pfizer.com.
Chem Biol ; 22(12): 1588-96, 2015 Dec 17.
Article in En | MEDLINE | ID: mdl-26670081
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / CREB-Binding Protein / Small Molecule Libraries Limits: Humans Language: En Journal: Chem Biol Journal subject: BIOLOGIA / BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / CREB-Binding Protein / Small Molecule Libraries Limits: Humans Language: En Journal: Chem Biol Journal subject: BIOLOGIA / BIOQUIMICA / QUIMICA Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States