Atopy: a risk factor of refractory mycoplasma pneumoniae pneumonia?
Clin Respir J
; 11(6): 931-934, 2017 Nov.
Article
in En
| MEDLINE
| ID: mdl-26683420
ABSTRACT
OBJECTIVE:
To investigate the relationship of pathogen DNA copies with clinic and laboratory features among children with Mycoplasma pneumoniae (MP) pneumonia.METHODS:
A total of 95 enrolled children with MP pneumonia were assigned into the high-MP-load group (>106 /mL) and the low-MP-load group (≤106 /mL) according to MP-DNA copies in bronchoalveolar lavage fluid (BALF). Clinical characteristics and any allergy history were collected. Aeroallergens and food allergens were detected with a skin test. Serum IgE and eosinophil cationic protein (ECP) were assessed using enzyme immunoassay. BALF levels of IL-4, IFN-γ, IL-8 and TNF-α were assessed by ELISA.RESULTS:
Compared with the low-MP-load group, 72.7% in the high-MP-load group developed refractory MP pneumonia who failed to respond to at least 1-week treatment with macrolides (72.7% vs 41.9%, P = 0.005). More children in the high-load group than those in the low-load group presented with extrapulmonary manifestations, lung consolidation, pleural effusion and atopic conditions including any allergy history, positive findings of aeroallergen test and increased serum IgE and ECP (P < 0.05). A significant higher BALF IL-4 level was seen in the high-load group versus the low-load group (23.00 ± 11.24 vs 14.68 ± 7.12; pg/mL; P < 0.01). There were no significant differences in BALF levels of IFN-γ, IL-8 and TNF-α between the two groups (P > 0.05).CONCLUSION:
Atopy may be a risk factor for the presence and severity of refractory MP pneumonia due to the high pathogen load in airway.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia, Mycoplasma
/
Hypersensitivity, Immediate
/
Mycoplasma pneumoniae
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Child
/
Child, preschool
/
Female
/
Humans
Language:
En
Journal:
Clin Respir J
Year:
2017
Document type:
Article
Affiliation country:
China