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Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs.
Marsden, Clare D; Ortega-Del Vecchyo, Diego; O'Brien, Dennis P; Taylor, Jeremy F; Ramirez, Oscar; Vilà, Carles; Marques-Bonet, Tomas; Schnabel, Robert D; Wayne, Robert K; Lohmueller, Kirk E.
Affiliation
  • Marsden CD; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095;
  • Ortega-Del Vecchyo D; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA 90095;
  • O'Brien DP; Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO 65211;
  • Taylor JF; Division of Animal Sciences, University of Missouri, Columbia, MO 65211;
  • Ramirez O; Institut Catala de Recerca i Estudis Avançats, Institut de Biologia Evolutiva (Centro Superior de Investigaciones Cientificas-Universitat Pompeu Fabra), 08003 Barcelona, Spain;
  • Vilà C; Conservation and Evolutionary Genetics Group, Estación Biológica de Doñana-Consejo Superior de Investigaciones Cientificas, 41092, Seville, Spain;
  • Marques-Bonet T; Institut Catala de Recerca i Estudis Avançats, Institut de Biologia Evolutiva (Centro Superior de Investigaciones Cientificas-Universitat Pompeu Fabra), 08003 Barcelona, Spain; Centro Nacional Analasis Genomico, 08023, Barcelona, Spain;
  • Schnabel RD; Division of Animal Sciences, University of Missouri, Columbia, MO 65211; Informatics Institute, University of Missouri, Columbia, MO 65211;
  • Wayne RK; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095;
  • Lohmueller KE; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA 90095; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 9009
Proc Natl Acad Sci U S A ; 113(1): 152-7, 2016 01 05.
Article in En | MEDLINE | ID: mdl-26699508
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Dog Diseases / Dogs / Datasets as Topic / Selective Breeding / Animals, Domestic Type of study: Guideline Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Dog Diseases / Dogs / Datasets as Topic / Selective Breeding / Animals, Domestic Type of study: Guideline Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article Country of publication: United States