Small Molecule Agonists for the Type I Interferon Receptor: An In Silico Approach.

Wei, Lianhu; Bello, Angelica M; Majchrzak-Kita, Beata; Salum, Noruê; Lewis, Melissa M; Kotra, Lakshmi P; Fish, Eleanor N

Wei, Lianhu; Bello, Angelica M; Majchrzak-Kita, Beata; Salum, Noruê; Lewis, Melissa M; Kotra, Lakshmi P; Fish, Eleanor N.

Affiliation

Wei L; 1 Center for Molecular Design and Preformulations , Toronto, Canada .
Bello AM; 2 Toronto General Research Institute, University Health Network , Toronto, Canada .
Majchrzak-Kita B; 3 Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Canada .
Salum N; 1 Center for Molecular Design and Preformulations , Toronto, Canada .
Lewis MM; 2 Toronto General Research Institute, University Health Network , Toronto, Canada .
Kotra LP; 3 Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Canada .
Fish EN; 2 Toronto General Research Institute, University Health Network , Toronto, Canada .

J Interferon Cytokine Res ; 36(3): 180-91, 2016 Mar.

Article in En | MEDLINE | ID: mdl-26700737

Subject(s)

Antiviral Agents/pharmacology; Encephalomyocarditis virus/drug effects; Interferon-alpha/chemistry; Peptidomimetics/pharmacology; Receptor, Interferon alpha-beta/agonists; Small Molecule Libraries/pharmacology; Antiviral Agents/chemical synthesis; B-Lymphocytes/drug effects; B-Lymphocytes/pathology; B-Lymphocytes/virology; Cell Line, Tumor; Computer Simulation; Drug Design; Encephalomyocarditis virus/growth & development; Gene Expression; High-Throughput Screening Assays; Humans; Ligands; Models, Molecular; Peptidomimetics/chemical synthesis; Protein Structure, Secondary; Receptor, Interferon alpha-beta/chemistry; Receptor, Interferon alpha-beta/genetics; Receptor, Interferon alpha-beta/metabolism; Recombinant Proteins/chemistry; Small Molecule Libraries/chemical synthesis; Structure-Activity Relationship; User-Computer Interface

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Interferon-alpha / Encephalomyocarditis virus / Receptor, Interferon alpha-beta / Small Molecule Libraries / Peptidomimetics Limits: Humans Language: En Journal: J Interferon Cytokine Res Journal subject: ALERGIA E IMUNOLOGIA Year: 2016 Document type: Article Affiliation country: Canada Country of publication: United States

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