Classical and lectin complement pathway activity in polyneuropathy associated with IgM monoclonal gammopathy.
J Neuroimmunol
; 290: 76-9, 2016 Jan 15.
Article
in En
| MEDLINE
| ID: mdl-26711574
ABSTRACT
Polyneuropathy associated with IgM monoclonal gammopathy (IgM-PNP) is a slowly progressive, sensorimotor neuropathy. It is assumed that complement activation contributes to IgM-PNP pathogenesis. We investigated whether innate differences in complement activity of the classical and mannose binding lectin (MBL) pathways are associated with IgM-PNP or its severity. We measured complement activity using ELISA and determined MBL serumc oncentrations and MBL gene polymorphisms in 83 patients and 83 healthy controls. We did not observe differences between IgM-PNP patients and healthy controls nor associations with different disease severities. Differences in innate complement activity are not likely to explain susceptibility to or severity of IgM-PNP.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paraproteinemias
/
Polyneuropathies
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Immunoglobulin M
/
Complement Activation
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Complement Pathway, Mannose-Binding Lectin
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
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Aged80
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Female
/
Humans
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Male
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Middle aged
Language:
En
Journal:
J Neuroimmunol
Year:
2016
Document type:
Article