Renalase Levels in Children with Solitary Functioning Kidney.

OBJECTIVE: To measure serum and urine renalase levels in children with a single kidney, and to compare with a reference group. METHODS: Participants were: solitary kidney (n=36) and healthy children (n=57). Renalase levels were measured using the immunoenzymatic method. RESULTS: Serum and urine renalase levels were significantly lower in patients with a solitary kidney compared to healthy children. Urine renalase/creatinine values were negatively related to serum creatinine and positively related to glomerular filtration rate. Significant correlations between renalase levels and blood pressure were not found. CONCLUSION: Prognostic importance of reduced renalase levels in children with a single kidney can only be quantified by further longitudinal study.