A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.

Alhazzazi, Turki Y; Kamarajan, Pachiyappan; Xu, Yanli; Ai, Teng; Chen, Liqiang; Verdin, Eric; Kapila, Yvonne L

Alhazzazi, Turki Y; Kamarajan, Pachiyappan; Xu, Yanli; Ai, Teng; Chen, Liqiang; Verdin, Eric; Kapila, Yvonne L.

Affiliation

Alhazzazi TY; Department of Oral Biology, King Abdulaziz University, Faculty of Dentistry, Jeddah, Saudi Arabia Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, U.S.A.
Kamarajan P; Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, U.S.A.
Xu Y; Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN, U.S.A.
Ai T; Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN, U.S.A.
Chen L; Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN, U.S.A.
Verdin E; Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, U.S.A.
Kapila YL; Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, U.S.A. ykapila@umich.edu.

Anticancer Res ; 36(1): 49-60, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26722027

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Carcinoma, Squamous Cell/drug therapy; Cell Proliferation/drug effects; Head and Neck Neoplasms/drug therapy; Heterocyclic Compounds, 4 or More Rings/pharmacology; Histone Deacetylase Inhibitors/pharmacology; Indoles/pharmacology; Laryngeal Neoplasms/drug therapy; Mouth Neoplasms/drug therapy; Sirtuin 3/antagonists & inhibitors; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell/enzymology; Carcinoma, Squamous Cell/pathology; Carcinoma, Squamous Cell/radiotherapy; Cell Line, Tumor; Chemoradiotherapy; Cisplatin/pharmacology; Dose-Response Relationship, Drug; Head and Neck Neoplasms/enzymology; Head and Neck Neoplasms/pathology; Head and Neck Neoplasms/radiotherapy; Humans; Keratinocytes/drug effects; Keratinocytes/metabolism; Keratinocytes/pathology; Laryngeal Neoplasms/enzymology; Laryngeal Neoplasms/pathology; Laryngeal Neoplasms/radiotherapy; Mouth Neoplasms/enzymology; Mouth Neoplasms/pathology; Mouth Neoplasms/radiotherapy; Radiation Tolerance; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Sirtuin 3/metabolism; Squamous Cell Carcinoma of Head and Neck

Key words

HNSCC; ROS; SIRT3; Sirtuins; oral cancer; sirtuin inhibitor; sirtuin-3

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell / Laryngeal Neoplasms / Apoptosis / Cell Proliferation / Sirtuin 3 / Histone Deacetylase Inhibitors / Head and Neck Neoplasms / Heterocyclic Compounds, 4 or More Rings / Indoles Limits: Humans Language: En Journal: Anticancer Res Year: 2016 Document type: Article Affiliation country: United States Country of publication: Greece

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