TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?
J Bioenerg Biomembr
; 48(1): 1-12, 2016 Feb.
Article
in En
| MEDLINE
| ID: mdl-26728159
ABSTRACT
Ion channels allow for rapid ion diffusion through the plasma membrane. In some conditions, ion channels induce changes in the critical plasma membrane permeability that permit 900-Da solutes to enter cells. This process is known as the pore phenomenon. Some transient receptor potential (TRP) channel subtypes have been highlighted such as the P2X7 receptor, plasma membrane VDAC-1 channel, and pannexin hemichannels. The TRP ion channels are considered multimodal transducers that respond to several kinds of stimuli. In addition, many TRP channel subtypes are involved in physiological and pathophysiological processes such as inflammation, pain, and cancer. The TRPA1, TRPM8, and TRPV1-4 subtypes have been shown to promote large-molecular-weight solute uptake, including impermeable fluorescent dyes, QX-314 hydrophilic lidocaine derivative, gabapentin, and antineoplastic drugs. This review discusses the current knowledge of TRP-associated pores and encourages scientists to study their features and explore them as novel therapeutic tools.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Membrane Permeability
/
Voltage-Dependent Anion Channels
/
Ligand-Gated Ion Channels
/
Membrane Potentials
Limits:
Animals
/
Humans
Language:
En
Journal:
J Bioenerg Biomembr
Year:
2016
Document type:
Article
Affiliation country:
Brazil