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Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.
Shu, Shaokun; Lin, Charles Y; He, Housheng Hansen; Witwicki, Robert M; Tabassum, Doris P; Roberts, Justin M; Janiszewska, Michalina; Huh, Sung Jin; Liang, Yi; Ryan, Jeremy; Doherty, Ernest; Mohammed, Hisham; Guo, Hao; Stover, Daniel G; Ekram, Muhammad B; Brown, Jonathan; D'Santos, Clive; Krop, Ian E; Dillon, Deborah; McKeown, Michael; Ott, Christopher; Qi, Jun; Ni, Min; Rao, Prakash K; Duarte, Melissa; Wu, Shwu-Yuan; Chiang, Cheng-Ming; Anders, Lars; Young, Richard A; Winer, Eric; Letai, Antony; Barry, William T; Carroll, Jason S; Long, Henry; Brown, Myles; Liu, X Shirley; Meyer, Clifford A; Bradner, James E; Polyak, Kornelia.
Affiliation
  • Shu S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Lin CY; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • He HH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Witwicki RM; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Tabassum DP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Roberts JM; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Janiszewska M; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts USA.
  • Huh SJ; Princess Margaret Cancer Center/University Health Network, Toronto, Ontario, M5G1L7, Canada.
  • Liang Y; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G2M9, Canada.
  • Ryan J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Doherty E; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Mohammed H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Guo H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Stover DG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Ekram MB; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Brown J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • D'Santos C; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Krop IE; Princess Margaret Cancer Center/University Health Network, Toronto, Ontario, M5G1L7, Canada.
  • Dillon D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • McKeown M; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Ott C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Qi J; Harvard University, Cambridge, Massachusetts, USA.
  • Ni M; Cancer Research UK, Cambridge Institute, University of Cambridge, UK, CB2 0RE.
  • Rao PK; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts USA.
  • Duarte M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Wu SY; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Chiang CM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Anders L; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Young RA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Winer E; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Letai A; Cancer Research UK, Cambridge Institute, University of Cambridge, UK, CB2 0RE.
  • Barry WT; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Carroll JS; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Long H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Brown M; Department of Pathology, Brigham and Women's Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
  • Liu XS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Meyer CA; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Bradner JE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Polyak K; Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Nature ; 529(7586): 413-417, 2016 Jan 21.
Article in En | MEDLINE | ID: mdl-26735014
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Transcription Factors / Triazoles / Nuclear Proteins / Protein Structure, Tertiary / Drug Resistance, Neoplasm / Triple Negative Breast Neoplasms Type of study: Prognostic_studies Language: En Journal: Nature Year: 2016 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Transcription Factors / Triazoles / Nuclear Proteins / Protein Structure, Tertiary / Drug Resistance, Neoplasm / Triple Negative Breast Neoplasms Type of study: Prognostic_studies Language: En Journal: Nature Year: 2016 Document type: Article Affiliation country: United States Country of publication: United kingdom