Shedding of Oral Poliovirus Vaccine (OPV) by HIV-Infected and -Uninfected Mothers of OPV-Vaccinated Zimbabwean Infants.
J Pediatric Infect Dis Soc
; 6(1): 105-108, 2017 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-26759497
ABSTRACT
Community circulation of oral poliovirus vaccine (OPV) likely begins with household transmission. We analyzed stool collected from Zimbabwean mothers who were infected with human immunodeficiency virus (HIV) and those who were uninfected with HIV 1 to 24 weeks after infant oral poliovirus vaccination. Overall, only 5% of the mothers had detectable OPV (16 of 304) despite high infant shedding rates. OPV shedding was similar between HIV-infected mothers and those who were uninfected (11 [6.4%] of 171 vs 5 [3.8%] of 133, respectively) and between mothers of HIV-infected infants and those of uninfected infants (2 [3.5%] of 57 vs 9 [6.3%] of 144, respectively). Mothers of vaccinated infants are unlikely to shed OPV, even when they are infected with HIV.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Poliovirus Vaccine, Oral
/
HIV Infections
/
Virus Shedding
/
Infectious Disease Transmission, Vertical
/
Developing Countries
/
Mothers
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspects:
Determinantes_sociais_saude
Limits:
Adult
/
Female
/
Humans
/
Infant
/
Male
/
Pregnancy
Country/Region as subject:
Africa
Language:
En
Journal:
J Pediatric Infect Dis Soc
Year:
2017
Document type:
Article