[Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines].
Bioorg Khim
; 41(5): 612-8, 2015.
Article
in Ru
| MEDLINE
| ID: mdl-26762100
ABSTRACT
Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity starting from commercially available R- and S-isomers of N-Boc-2-aminopropanol-1. Application of R- and S-isomers of 3-MeSpd for the investigation of the stereospecificity of spermidine transporter and peculiarities of deoxyhypusine synthase reaction are discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spermidine
Limits:
Humans
Language:
Ru
Journal:
Bioorg Khim
Year:
2015
Document type:
Article