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Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.
Baumgardt, Shelley L; Paterson, Mark; Leucker, Thorsten M; Fang, Juan; Zhang, David X; Bosnjak, Zeljko J; Warltier, David C; Kersten, Judy R; Ge, Zhi-Dong.
Affiliation
  • Baumgardt SL; From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Dep
  • Paterson M; From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Dep
  • Leucker TM; From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Dep
  • Fang J; From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Dep
  • Zhang DX; From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Dep
  • Bosnjak ZJ; From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Dep
  • Warltier DC; From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Dep
  • Kersten JR; From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Dep
  • Ge ZD; From the Department of Anesthesiology (S.L.B., M.P., Z.J.B., D.C.W., J.R.K., Z.-D.G.), Department of Pediatrics (J.F.), Department of Medicine (D.X.Z.), Department of Physiology (Z.J.B.), and Department of Pharmacology and Toxicology (D.C.W., J.R.K.), Medical College of Wisconsin, Milwaukee; and Dep
Circ Heart Fail ; 9(1): e002424, 2016 Jan.
Article in En | MEDLINE | ID: mdl-26763290
Subject(s)
Cardiotonic Agents/administration & dosage; Citrulline/administration & dosage; Diabetes Mellitus, Type 2/drug therapy; Diabetic Cardiomyopathies/prevention & control; Myocardial Infarction/prevention & control; Myocardial Reperfusion Injury/prevention & control; Obesity/complications; Pterins/administration & dosage; Age Factors; Animals; Biopterins/analogs & derivatives; Biopterins/metabolism; Cells, Cultured; Coronary Circulation/drug effects; Coronary Vessels/drug effects; Coronary Vessels/metabolism; Coronary Vessels/physiopathology; Diabetes Mellitus, Type 2/complications; Diabetes Mellitus, Type 2/metabolism; Diabetic Cardiomyopathies/etiology; Diabetic Cardiomyopathies/metabolism; Diabetic Cardiomyopathies/pathology; Diabetic Cardiomyopathies/physiopathology; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Isolated Heart Preparation; Mice, Inbred C57BL; Mice, Obese; Myocardial Infarction/etiology; Myocardial Infarction/metabolism; Myocardial Infarction/pathology; Myocardial Infarction/physiopathology; Myocardial Reperfusion Injury/etiology; Myocardial Reperfusion Injury/metabolism; Myocardial Reperfusion Injury/pathology; Myocardial Reperfusion Injury/physiopathology; Myocardium/metabolism; Myocardium/pathology; Nitric Oxide/metabolism; Nitric Oxide Synthase Type III/metabolism; Phosphorylation; Protein Multimerization; Time Factors; Vasodilation/drug effects; Ventricular Function, Left/drug effects
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pterins / Cardiotonic Agents / Myocardial Reperfusion Injury / Citrulline / Diabetes Mellitus, Type 2 / Diabetic Cardiomyopathies / Myocardial Infarction / Obesity Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Circ Heart Fail Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2016 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pterins / Cardiotonic Agents / Myocardial Reperfusion Injury / Citrulline / Diabetes Mellitus, Type 2 / Diabetic Cardiomyopathies / Myocardial Infarction / Obesity Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Circ Heart Fail Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2016 Document type: Article Country of publication: United States