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Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma.
Grohar, Patrick J; Kim, Suntae; Rangel Rivera, Guillermo O; Sen, Nirmalya; Haddock, Sara; Harlow, Matt L; Maloney, Nichole K; Zhu, Jack; O'Neill, Maura; Jones, Tamara L; Huppi, Konrad; Grandin, Magdalena; Gehlhaus, Kristen; Klumpp-Thomas, Carleen A; Buehler, Eugen; Helman, Lee J; Martin, Scott E; Caplen, Natasha J.
Affiliation
  • Grohar PJ; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Kim S; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Rangel Rivera GO; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA; NIH Academy, Office of Intramural Training and Education, NIH, Bethesda, MD 20892, USA.
  • Sen N; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Haddock S; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Harlow ML; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Maloney NK; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Zhu J; Molecular Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • O'Neill M; Protein Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  • Jones TL; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Huppi K; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Grandin M; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Gehlhaus K; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Klumpp-Thomas CA; Trans-NIH RNAi Screening Facility, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Buehler E; Trans-NIH RNAi Screening Facility, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Helman LJ; Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Martin SE; Trans-NIH RNAi Screening Facility, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
  • Caplen NJ; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: ncaplen@mail.nih.gov.
Cell Rep ; 14(3): 598-610, 2016 Jan 26.
Article in En | MEDLINE | ID: mdl-26776507
Subject(s)
Oncogene Proteins, Fusion/metabolism; Proto-Oncogene Protein c-fli-1/metabolism; RNA-Binding Protein EWS/metabolism; Base Sequence; Binding Sites; Calmodulin-Binding Proteins/antagonists & inhibitors; Calmodulin-Binding Proteins/genetics; Calmodulin-Binding Proteins/metabolism; Cell Line, Tumor; Cell Survival; Exons; Gene Expression Regulation, Neoplastic; Heterogeneous-Nuclear Ribonucleoprotein Group F-H/antagonists & inhibitors; Heterogeneous-Nuclear Ribonucleoprotein Group F-H/genetics; Heterogeneous-Nuclear Ribonucleoprotein Group F-H/metabolism; Humans; Microfilament Proteins/antagonists & inhibitors; Microfilament Proteins/genetics; Microfilament Proteins/metabolism; Oncogene Proteins, Fusion/antagonists & inhibitors; Oncogene Proteins, Fusion/genetics; Phosphoproteins/antagonists & inhibitors; Phosphoproteins/genetics; Phosphoproteins/metabolism; Proto-Oncogene Protein c-fli-1/antagonists & inhibitors; Proto-Oncogene Protein c-fli-1/genetics; RNA Interference; RNA Precursors/metabolism; RNA Splicing; RNA Splicing Factors; RNA, Small Interfering/metabolism; RNA-Binding Protein EWS/antagonists & inhibitors; RNA-Binding Protein EWS/genetics; RNA-Binding Proteins/antagonists & inhibitors; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors; Receptors, Cytoplasmic and Nuclear/genetics; Receptors, Cytoplasmic and Nuclear/metabolism; Ribonucleoprotein, U2 Small Nuclear/antagonists & inhibitors; Ribonucleoprotein, U2 Small Nuclear/genetics; Ribonucleoprotein, U2 Small Nuclear/metabolism; Sarcoma, Ewing/pathology; Trans-Activators; Transcription Factors/antagonists & inhibitors; Transcription Factors/genetics; Transcription Factors/metabolism
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogene Proteins, Fusion / RNA-Binding Protein EWS / Proto-Oncogene Protein c-fli-1 Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Cell Rep Year: 2016 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogene Proteins, Fusion / RNA-Binding Protein EWS / Proto-Oncogene Protein c-fli-1 Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Cell Rep Year: 2016 Document type: Article Affiliation country: United States