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A new ratiometric fluorescent probe for rapid, sensitive and selective detection of endogenous hydrogen sulfide in mitochondria.
Feng, Xiao; Zhang, Tao; Liu, Jin-Ting; Miao, Jun-Ying; Zhao, Bao-Xiang.
Affiliation
  • Feng X; Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China. bxzhao@sdu.edu.cn.
  • Zhang T; Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, P. R. China. miaojy@sdu.edu.cn.
  • Liu JT; Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China. bxzhao@sdu.edu.cn.
  • Miao JY; Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, P. R. China. miaojy@sdu.edu.cn.
  • Zhao BX; Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China. bxzhao@sdu.edu.cn.
Chem Commun (Camb) ; 52(15): 3131-4, 2016 Feb 21.
Article in En | MEDLINE | ID: mdl-26806758
ABSTRACT
We have developed a new ratiometric fluorescent probe composed of a coumarin-merocyanine dyad based on the FRET mechanism. The probe showed clear dual-emission signal changes in blue and red spectral windows upon addition of H2S in a dose dependent manner under a single wavelength excitation. The probe targeted mitochondria with high selectivity and sensitivity toward H2S.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fluorescent Dyes / Hydrogen Sulfide / Mitochondria Type of study: Diagnostic_studies Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2016 Document type: Article Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fluorescent Dyes / Hydrogen Sulfide / Mitochondria Type of study: Diagnostic_studies Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2016 Document type: Article Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM