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Polyunsaturated lysophosphatidic acid as a potential asthma biomarker.
Ackerman, Steven J; Park, Gye Young; Christman, John W; Nyenhuis, Sharmilee; Berdyshev, Evgeny; Natarajan, Viswanathan.
Affiliation
  • Ackerman SJ; Department of Biochemistry & Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
  • Park GY; Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
  • Christman JW; Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
  • Nyenhuis S; Department of Medicine, Ohio State University School of Medicine, Columbus, OH 43210, USA.
  • Berdyshev E; Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
  • Natarajan V; Department of Medicine, National Jewish Health, Denver, CO 80206, USA.
Biomark Med ; 10(2): 123-35, 2016.
Article in En | MEDLINE | ID: mdl-26808693
ABSTRACT
Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA and choline. Total LPA levels are increased in bronchoalveolar lavage fluid from asthmatic lung, and are strongly induced following subsegmental bronchoprovocation with allergen in subjects with allergic asthma. Polyunsaturated molecular species of LPA (C225 and C226) are selectively synthesized in the airways of asthma subjects following allergen challenge and in mouse models of allergic airway inflammation, having been identified and quantified by LC/MS/MS lipidomics. This review discusses current knowledge of LPA production in asthmatic lung and the potential utility of polyunsaturated LPA molecular species as novel biomarkers in bronchoalveolar lavage fluid and exhaled breath condensate of asthma subjects.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Bronchoalveolar Lavage Fluid / Lysophospholipids / Allergens / Inflammation / Lung Type of study: Prognostic_studies Limits: Adult / Animals / Humans Language: En Journal: Biomark Med Journal subject: BIOQUIMICA / MEDICINA Year: 2016 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Bronchoalveolar Lavage Fluid / Lysophospholipids / Allergens / Inflammation / Lung Type of study: Prognostic_studies Limits: Adult / Animals / Humans Language: En Journal: Biomark Med Journal subject: BIOQUIMICA / MEDICINA Year: 2016 Document type: Article Affiliation country: United States