Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia.

Leitch, Calum; Osdal, Tereza; Andresen, Vibeke; Molland, Maren; Kristiansen, Silje; Nguyen, Xuan Nhi; Bruserud, Øystein; Gjertsen, Bjørn Tore; McCormack, Emmet

Leitch, Calum; Osdal, Tereza; Andresen, Vibeke; Molland, Maren; Kristiansen, Silje; Nguyen, Xuan Nhi; Bruserud, Øystein; Gjertsen, Bjørn Tore; McCormack, Emmet.

Affiliation

Leitch C; Department of Clinical Science, University of Bergen, Bergen, N-5021 Norway.
Osdal T; Centre of Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, N-5021 Norway.
Andresen V; Department of Clinical Science, University of Bergen, Bergen, N-5021 Norway.
Molland M; Department of Clinical Science, University of Bergen, Bergen, N-5021 Norway.
Kristiansen S; Centre of Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, N-5021 Norway.
Nguyen XN; Department of Clinical Science, University of Bergen, Bergen, N-5021 Norway.
Bruserud Ø; Department of Clinical Science, University of Bergen, Bergen, N-5021 Norway.
Gjertsen BT; Department of Clinical Science, University of Bergen, Bergen, N-5021 Norway.
McCormack E; Department of Clinical Science, University of Bergen, Bergen, N-5021 Norway.

Oncotarget ; 7(7): 8105-18, 2016 Feb 16.

Article in En | MEDLINE | ID: mdl-26812881

Subject(s)

Drug Synergism; Hydroxyurea/pharmacology; Leukemia, Myeloid, Acute/drug therapy; Tumor Suppressor Protein p53/genetics; Valproic Acid/pharmacology; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anticonvulsants/pharmacology; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Blotting, Western; Case-Control Studies; Cell Proliferation/drug effects; Female; Fluorescent Antibody Technique; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/pathology; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Mutation/genetics; Neoplasm Staging; Prognosis; Survival Rate; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Key words

AML; DNA damage; hydroxyurea; p53; valproic acid

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Tumor Suppressor Protein p53 / Valproic Acid / Drug Synergism / Hydroxyurea Type of study: Observational_studies / Prognostic_studies Limits: Adolescent / Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Oncotarget Year: 2016 Document type: Article Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google