Chronic administration of isocarbophos induces vascular cognitive impairment in rats.

Li, Peng; Yin, Ya-Ling; Zhu, Mo-Li; Pan, Guo-Pin; Zhao, Fan-Rong; Lu, Jun-Xiu; Liu, Zhan; Wang, Shuang-Xi; Hu, Chang-Ping

Li, Peng; Yin, Ya-Ling; Zhu, Mo-Li; Pan, Guo-Pin; Zhao, Fan-Rong; Lu, Jun-Xiu; Liu, Zhan; Wang, Shuang-Xi; Hu, Chang-Ping.

Affiliation

Li P; Department of Pharmacology, Pharmaceutical College, Central South University, Changsha, China.
Yin YL; College of Pharmacy, Xinxiang Medical University, Xinxiang, China.
Zhu ML; College of Basic Medical Sciences, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China.
Pan GP; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China.
Zhao FR; Sanqun Medical College, Xinxiang Medical University, Xinxiang, China.
Lu JX; Department of Pharmacology, Pharmaceutical College, Central South University, Changsha, China.
Liu Z; Sanqun Medical College, Xinxiang Medical University, Xinxiang, China.
Wang SX; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China.
Hu CP; Department of Clinical Nutrition, The Affiliated Hospital, Hunan Normal University, Changsha, China.

J Cell Mol Med ; 20(4): 731-9, 2016 Apr.

Article in En | MEDLINE | ID: mdl-26818681

Subject(s)

Cognitive Dysfunction/chemically induced; Hippocampus/drug effects; Malathion/analogs & derivatives; Middle Cerebral Artery/drug effects; Pesticides/toxicity; Posterior Cerebral Artery/drug effects; Acetylcholine/antagonists & inhibitors; Acetylcholine/metabolism; Acetylcholinesterase/genetics; Acetylcholinesterase/metabolism; Animals; Astrocytes/drug effects; Astrocytes/metabolism; Astrocytes/pathology; Cerebrovascular Circulation; Cognitive Dysfunction/genetics; Cognitive Dysfunction/metabolism; Cognitive Dysfunction/pathology; Gene Expression; Hippocampus/blood supply; Hippocampus/metabolism; Hippocampus/pathology; Intercellular Adhesion Molecule-1/genetics; Intercellular Adhesion Molecule-1/metabolism; Malathion/toxicity; Maze Learning/drug effects; Memory/drug effects; Middle Cerebral Artery/metabolism; Middle Cerebral Artery/pathology; Neurons/drug effects; Neurons/metabolism; Neurons/pathology; Posterior Cerebral Artery/metabolism; Posterior Cerebral Artery/pathology; Primary Cell Culture; Rats; Vascular Cell Adhesion Molecule-1/genetics; Vascular Cell Adhesion Molecule-1/metabolism

Key words

ageing; endothelial dysfunction; organophosphorus; vascular cognitive impairment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pesticides / Middle Cerebral Artery / Posterior Cerebral Artery / Cognitive Dysfunction / Hippocampus / Malathion Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2016 Document type: Article Affiliation country: China Country of publication: United kingdom

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