Colistin-Nonsusceptible Pseudomonas aeruginosa Sequence Type 654 with blaNDM-1 Arrives in North America.
Antimicrob Agents Chemother
; 60(3): 1794-800, 2016 Jan 11.
Article
in En
| MEDLINE
| ID: mdl-26824951
ABSTRACT
This study describes 3 different blaNDM-1 genetic platforms in 3 different species obtained from the same patient who was directly transferred to an institution in Calgary, Alberta, Canada, following a prolonged hospital stay in India. The blaNDM-1 in the Escherichia coli isolate was located on a 176-kb IncA/C plasmid contained within an ISCR1 region. The blaNDM-1 in the Providencia rettgeri isolate was located on a 117-kb IncT plasmid contained within Tn3000, while the blaNDM-1 in the Pseudomonas aeruginosa isolate was located on the chromosome within an ISCR3 region. This report highlights the plasticity of the genetic regions and environments associated with blaNDM-1. To the best of our knowledge, this is the first report of P. aeruginosa with blaNDM-1 identified in North America and the first report of blaOXA-181 in P. rettgeri. The P. aeruginosa isolate belonged to the international high-risk sequence type 654 clone and was nonsusceptible to colistin. This case emphasizes the need for the use of appropriate infection prevention and control measures and vigilant screening for carbapenem-resistant Gram-negative bacteria in patients with a history of travel to areas of endemicity, such as the Indian subcontinent.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudomonas aeruginosa
/
Beta-Lactamases
/
Providencia
/
Colistin
/
Drug Resistance, Bacterial
/
Escherichia coli
/
Anti-Bacterial Agents
Type of study:
Prognostic_studies
Limits:
Aged
/
Humans
/
Male
Country/Region as subject:
America do norte
/
Asia
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2016
Document type:
Article
Affiliation country:
Canada