Human olfactory stem cells for injured facial nerve reconstruction in a rat model.
Head Neck
; 38 Suppl 1: E2011-20, 2016 04.
Article
in En
| MEDLINE
| ID: mdl-26829770
ABSTRACT
BACKGROUND:
The purpose of this study was to show the efficacy of olfactory stem cells for injured facial nerve reconstruction in a rat model.METHODS:
Olfactory stem cells were isolated from the olfactory mucosa of human participants. A 2-mm excision was performed on the right facial nerve of all rats. Reconstruction was performed with a conduit in group 1 (n = 9); a conduit and phosphate-buffered saline in group 2 (n = 9); and a conduit and labeled olfactory stem cell in group 3 (n = 9). Rats were followed for whisker movements and electroneuronography (ENoG) analyses.RESULTS:
The whisker-movement scores for group 3 were significantly different from other groups (p < .001). ENoG showed that the amplitude values for group 3 were significantly different from group 1 and group 2 (p = .030; p < .001). Group 3 showed marked olfactory stem cell under a fluorescence microscope.CONCLUSION:
This study suggests that olfactory stem cells may be used as a potent cellular therapy for accelerating the regeneration of peripheral nerve injuries. © 2016 Wiley Periodicals, Inc. Head Neck 38 E2011-E2020, 2016.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Olfactory Mucosa
/
Facial Nerve Injuries
/
Stem Cell Transplantation
/
Facial Nerve
/
Nerve Regeneration
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2016
Document type:
Article
Affiliation country:
Turkey