Gene-expression Classifier in Papillary Thyroid Carcinoma: Validation and Application of a Classifier for Prognostication.
Anticancer Res
; 36(2): 749-56, 2016 Feb.
Article
in En
| MEDLINE
| ID: mdl-26851034
ABSTRACT
BACKGROUND:
No reliable biomarker for metastatic potential in the risk stratification of papillary thyroid carcinoma exists. We aimed to develop a gene-expression classifier for metastatic potential. MATERIALS ANDMETHODS:
Genome-wide expression analyses were used. Development cohort freshly frozen tissue from 38 patients was collected between the years 1986 and 2009. Validation cohort formalin-fixed paraffin-embedded tissues were collected from 183 consecutively treated patients.RESULTS:
A 17-gene classifier was identified based on the expression values in patients with and without metastasis in the development cohort. The 17-gene classifier for regional/distant metastasis identified was tested against the clinical status in the validation cohort. Sensitivity for detection of metastases was 51.5% and specificity 61.6%. Log-rank testing failed to identify any significance (p=0.32) regarding the classifier's usefulness as a prognostic marker for recurrence.CONCLUSION:
A 17-gene classifier for metastatic potential was developed, and the results showed a clear biological difference between groups. However, through validation, no prognostic significance of this classifier was shown.Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroid Neoplasms
/
Carcinoma
/
Biomarkers, Tumor
/
Gene Expression Profiling
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Anticancer Res
Year:
2016
Document type:
Article
Affiliation country:
Denmark