[Hypercapnia--alternative hypoxia signal incentives to increase HIF-1α and erythropoietin in the brain].
Patol Fiziol Eksp Ter
; (3): 34-7, 2015.
Article
in Ru
| MEDLINE
| ID: mdl-26852593
ABSTRACT
Investigated the role of hypercapnic component in the mechanism of activation of HIF-1α and increase the synthesis of erythropoietin in the combined and the isolated impact of hypoxia and hypercapnia. It was found that the content of proteins of interest significantly increases both in isolated hypoxia and hypercapnia, and at their combined effect. Moreover, the hypercapnic hypoxia causes maximum activation of the synthesis and accumulation of erythropoietin HIF-1α, and permissive hypercapnia enhances their content more than hypoxic exposure.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Hypoxia, Brain
/
Erythropoietin
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Hypercapnia
/
Nerve Tissue Proteins
Limits:
Animals
Language:
Ru
Journal:
Patol Fiziol Eksp Ter
Year:
2015
Document type:
Article