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Virulence of representative Japanese Francisella tularensis and immunologic consequences of infection in mice.
Hotta, Akitoyo; Fujita, Osamu; Uda, Akihiko; Yamamoto, Yoshie; Sharma, Neekun; Tanabayashi, Kiyoshi; Yamada, Akio; Morikawa, Shigeru.
Affiliation
  • Hotta A; Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku, Tokyo 162-8640.
  • Fujita O; Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku, Tokyo 162-8640.
  • Uda A; Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku, Tokyo 162-8640.
  • Yamamoto Y; Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku, Tokyo 162-8640.
  • Sharma N; Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku, Tokyo 162-8640.
  • Tanabayashi K; United Graduate School of Veterinary Science Gifu University, 1-1 Yanagido, Gifu 501-1193.
  • Yamada A; Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku, Tokyo 162-8640.
  • Morikawa S; Laboratory of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan.
Microbiol Immunol ; 60(3): 168-76, 2016 Mar.
Article in En | MEDLINE | ID: mdl-26853540
Francisella tularensis, which causes tularemia, is widely distributed in the Northern hemisphere. F. tularensis strains isolated in Japan are genetically unique from non-Japanese strains; however, their phenotypic properties have not been well studied. Thus, mice were infected with representative Japanese strains of F. tularensis and their virulence and mouse immune responses to them assessed. Of four representative Japanese strains, the Ebina, Jap and Tsuchiya strains were susceptible to H2 O2 and did not grow well intracellularly. Only Yama strain grew intracellularly and was lethal to mice. Infection with Yama strain resulted in drastic increases in IFN-γ, CD4 and CD8 double-positive T cells and Th1 cells (CD3, CD4 and Tim3-positive cells), and a decrease in the ratio of CD8-positive CD4-negative T cells in mice. C57BL/6J mice that survived infection produced IgM antibodies to LPS and IgG2c antibodies to 43, 19 and 17 kDa proteinase K-sensitive components. These data are valuable for understanding the phenotypic properties of F. tularensis in Japan.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tularemia / Francisella tularensis Limits: Animals Country/Region as subject: Asia Language: En Journal: Microbiol Immunol Year: 2016 Document type: Article Country of publication: Australia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tularemia / Francisella tularensis Limits: Animals Country/Region as subject: Asia Language: En Journal: Microbiol Immunol Year: 2016 Document type: Article Country of publication: Australia