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In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans.
Cui, Donghui; Cabalu, Tamara; Yee, Ka Lai; Small, James; Li, Xiaodong; Liu, Bo; Maciolek, Cheri; Smith, Sheri; Liu, Wen; McCrea, Jacqueline B; Prueksaritanont, Thomayant.
Affiliation
  • Cui D; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, Merck & Co, Inc , West Point , PA , USA .
  • Cabalu T; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, Merck & Co, Inc , West Point , PA , USA .
  • Yee KL; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, Merck & Co, Inc , West Point , PA , USA .
  • Small J; b Structure Elucidation NMR Group, Process Chemistry, Merck & Co, Inc , West Point , PA , USA .
  • Li X; c Bristol-Myers Squibb, Full Development Statistics, Global Biometrics Science , Hopewell , NJ , USA , and.
  • Liu B; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, Merck & Co, Inc , West Point , PA , USA .
  • Maciolek C; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, Merck & Co, Inc , West Point , PA , USA .
  • Smith S; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, Merck & Co, Inc , West Point , PA , USA .
  • Liu W; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, Merck & Co, Inc , West Point , PA , USA .
  • McCrea JB; d Department of Clinical Pharmacology and Experimental Therapeutics (CPET) , Merck & Co, Inc , Kenilworth , NJ , USA.
  • Prueksaritanont T; a Department of Pharmacokinetics , Pharmacodynamics and Drug Metabolism, Merck & Co, Inc , West Point , PA , USA .
Xenobiotica ; 46(10): 882-95, 2016 Oct.
Article in En | MEDLINE | ID: mdl-26864332
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Triazoles / Sleep Aids, Pharmaceutical Limits: Adult / Female / Humans / Male Language: En Journal: Xenobiotica Year: 2016 Document type: Article Affiliation country: United States Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Triazoles / Sleep Aids, Pharmaceutical Limits: Adult / Female / Humans / Male Language: En Journal: Xenobiotica Year: 2016 Document type: Article Affiliation country: United States Country of publication: United kingdom