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Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.
Lissanu Deribe, Yonathan; Shi, Yanxia; Rai, Kunal; Nezi, Luigi; Amin, Samir B; Wu, Chia-Chin; Akdemir, Kadir C; Mahdavi, Mozhdeh; Peng, Qian; Chang, Qing Edward; Hornigold, Kirsti; Arold, Stefan T; Welch, Heidi C E; Garraway, Levi A; Chin, Lynda.
Affiliation
  • Lissanu Deribe Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; ylissanu@mdanderson.org lchin@mdanderson.org.
  • Shi Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborate Center for Cancer Medicine, Guangzhou 510060, China;
  • Rai K; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;
  • Nezi L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;
  • Amin SB; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;
  • Wu CC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;
  • Akdemir KC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;
  • Mahdavi M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;
  • Peng Q; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;
  • Chang QE; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, TX 77030;
  • Hornigold K; The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom;
  • Arold ST; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-6900 Saudi Arabia;
  • Welch HC; The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom;
  • Garraway LA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215; Broad Institute of MIT and Harvard, Boston, MA 02141.
  • Chin L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, TX 77030; ylissanu@mdanderson.org lchin@mdanderson.org.
Proc Natl Acad Sci U S A ; 113(9): E1296-305, 2016 Mar 01.
Article in En | MEDLINE | ID: mdl-26884185
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Guanine Nucleotide Exchange Factors / Mutation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Guanine Nucleotide Exchange Factors / Mutation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article