Differences in expression of gut-homing receptors on CD4+ T cells in black and white HIV-negative men who have sex with men.
AIDS
; 30(8): 1305-8, 2016 05 15.
Article
in En
| MEDLINE
| ID: mdl-26891038
ABSTRACT
HIV incidence rates are higher among black men who have sex with men (BMSM) as compared with MSM of other race/ethnicities in the USA. We found that blood memory CD4 cells from BMSM express higher levels of α4ß7, the gut-homing integrin, compared with white MSM. Higher expression of α4ß7 on blood CD4 cells correlated with higher percentage of proliferating CD4α4ß7 cells in rectal tissue suggesting increased trafficking of potential HIV target cells to rectal mucosa could increase HIV susceptibility among BMSM.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rectum
/
CD4-Positive T-Lymphocytes
/
Integrins
/
Receptors, Lymphocyte Homing
/
Intestinal Mucosa
Limits:
Adolescent
/
Adult
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
AIDS
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2016
Document type:
Article
Affiliation country:
United States