A multicenter Phase II study evaluating the efficacy, safety and pharmacokinetics of trastuzumab emtansine in Japanese patients with heavily pretreated HER2-positive locally recurrent or metastatic breast cancer.

Kashiwaba, Masahiro; Ito, Yoshinori; Takao, Shintaro; Doihara, Hiroyoshi; Rai, Yoshiaki; Kanatani, Kazumitsu; Takashima, Shigemitsu; Masuda, Norikazu

Kashiwaba, Masahiro; Ito, Yoshinori; Takao, Shintaro; Doihara, Hiroyoshi; Rai, Yoshiaki; Kanatani, Kazumitsu; Takashima, Shigemitsu; Masuda, Norikazu.

Affiliation

Kashiwaba M; Department of Surgery, Iwate Medical University School of Medicine, Morioka, Iwate nmasuda@alpha.ocn.ne.jp.
Ito Y; The Cancer Institute Hospital of JFCR, Koto-ku, Tokyo.
Takao S; Hyogo Cancer Center, Akashi, Hyogo.
Doihara H; Okayama University Hospital, Okayama, Okayama.
Rai Y; Sagara Hospital, Kagoshima, Kagoshima.
Kanatani K; Chugai Pharmaceutical Co. Ltd, Chuo-ku, Tokyo.
Takashima S; NHO Shikoku Cancer Center, Matsuyama, Ehime.
Masuda N; Department of Surgery, Breast Oncology, NHO Osaka National Hospital, Chuo-ku, Osaka, Japan.

Jpn J Clin Oncol ; 46(5): 407-14, 2016 May.

Article in En | MEDLINE | ID: mdl-26917603

Subject(s)

Antibodies, Monoclonal, Humanized/therapeutic use; Antineoplastic Agents/therapeutic use; Breast Neoplasms/drug therapy; Maytansine/analogs & derivatives; Receptor, ErbB-2/metabolism; Ado-Trastuzumab Emtansine; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized/adverse effects; Antibodies, Monoclonal, Humanized/pharmacokinetics; Antineoplastic Agents/adverse effects; Antineoplastic Agents/pharmacokinetics; Asian People; Breast Neoplasms/mortality; Breast Neoplasms/pathology; Disease-Free Survival; Female; Half-Life; Humans; Japan; Maytansine/adverse effects; Maytansine/pharmacokinetics; Maytansine/therapeutic use; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Survival Rate; Thrombocytopenia/etiology; Trastuzumab; Treatment Outcome

Key words

HER2-positive; Japanese; T-DM1; antibodydrug conjugate (ADC); metastatic breast cancer; trastuzumab emtansine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Receptor, ErbB-2 / Antibodies, Monoclonal, Humanized / Maytansine / Antineoplastic Agents Type of study: Clinical_trials / Etiology_studies Limits: Adult / Aged / Aged80 / Female / Humans / Middle aged Country/Region as subject: Asia Language: En Journal: Jpn J Clin Oncol Year: 2016 Document type: Article Country of publication: United kingdom

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