Relationship between Tumor Biomarkers and Efficacy in EMILIA, a Phase III Study of Trastuzumab Emtansine in HER2-Positive Metastatic Breast Cancer.

Baselga, José; Lewis Phillips, Gail D; Verma, Sunil; Ro, Jungsil; Huober, Jens; Guardino, Alice E; Samant, Meghna K; Olsen, Steve; de Haas, Sanne L; Pegram, Mark D

Baselga, José; Lewis Phillips, Gail D; Verma, Sunil; Ro, Jungsil; Huober, Jens; Guardino, Alice E; Samant, Meghna K; Olsen, Steve; de Haas, Sanne L; Pegram, Mark D.

Affiliation

Baselga J; Memorial Sloan Kettering Cancer Center, New York, New York. baselgaj@mskcc.org.
Lewis Phillips GD; Genentech, Inc., South San Francisco, California.
Verma S; Sunnybrook Odette Cancer Centre, Toronto, Canada.
Ro J; National Cancer Center, Goyang, Korea.
Huober J; Breast Center, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Guardino AE; Genentech, Inc., South San Francisco, California.
Samant MK; Genentech, Inc., South San Francisco, California.
Olsen S; Genentech, Inc., South San Francisco, California.
de Haas SL; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Pegram MD; Stanford Cancer Institute, Palo Alto, California.

Clin Cancer Res ; 22(15): 3755-63, 2016 08 01.

Article in En | MEDLINE | ID: mdl-26920887

Subject(s)

Antineoplastic Agents, Immunological/therapeutic use; Biomarkers, Tumor; Breast Neoplasms/drug therapy; Breast Neoplasms/metabolism; Maytansine/analogs & derivatives; Receptor, ErbB-2/metabolism; Trastuzumab/therapeutic use; Ado-Trastuzumab Emtansine; Animals; Antineoplastic Agents, Immunological/administration & dosage; Antineoplastic Agents, Immunological/adverse effects; Breast Neoplasms/mortality; Breast Neoplasms/pathology; Disease Models, Animal; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Maytansine/administration & dosage; Maytansine/adverse effects; Maytansine/therapeutic use; Mice; Neoplasm Metastasis; Neoplasm Staging; Phosphatidylinositol 3-Kinases; Proportional Hazards Models; Retreatment; Trastuzumab/administration & dosage; Trastuzumab/adverse effects; Xenograft Model Antitumor Assays

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Biomarkers, Tumor / Receptor, ErbB-2 / Trastuzumab / Antineoplastic Agents, Immunological / Maytansine Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2016 Document type: Article Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google