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Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA).
Majer, Pavel; Jancarík, Andrej; Krecmerová, Marcela; Tichý, Tomás; Tenora, Lukás; Wozniak, Krystyna; Wu, Ying; Pommier, Elie; Ferraris, Dana; Rais, Rana; Slusher, Barbara S.
Affiliation
  • Majer P; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 166 10 Prague, Czech Republic.
  • Jancarík A; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 166 10 Prague, Czech Republic.
  • Krecmerová M; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 166 10 Prague, Czech Republic.
  • Tichý T; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 166 10 Prague, Czech Republic.
  • Tenora L; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., 166 10 Prague, Czech Republic.
  • Wozniak K; Johns Hopkins Drug Discovery, Johns Hopkins University , Baltimore, Maryland 21205, United States.
  • Wu Y; Johns Hopkins Drug Discovery, Johns Hopkins University , Baltimore, Maryland 21205, United States.
  • Pommier E; Johns Hopkins Drug Discovery, Johns Hopkins University , Baltimore, Maryland 21205, United States.
  • Ferraris D; Department of Chemistry, McDaniel College , Westminster, Maryland 21157, United States.
  • Rais R; Johns Hopkins Drug Discovery, Johns Hopkins University , Baltimore, Maryland 21205, United States.
  • Slusher BS; Johns Hopkins Department of Neurology, Johns Hopkins University , Baltimore, Maryland 21205, United States.
J Med Chem ; 59(6): 2810-9, 2016 Mar 24.
Article in En | MEDLINE | ID: mdl-26930119
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Prodrugs / Glutamate Carboxypeptidase II Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: Czech Republic Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Prodrugs / Glutamate Carboxypeptidase II Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: Czech Republic Country of publication: United States