Vanillin and 4-hydroxybenzyl alcohol promotes cell proliferation and neuroblast differentiation in the dentate gyrus of mice via the increase of brain-derived neurotrophic factor and tropomyosin-related kinase B.
Mol Med Rep
; 13(4): 2949-56, 2016 Apr.
Article
in En
| MEDLINE
| ID: mdl-26935641
ABSTRACT
4-Hydroxy3-methoxybenzaldehyde (vanillin) and 4-hydroxybenzyl alcohol (4-HBA) are wellknown phenolic compounds, which possess various therapeutic properties and are widely found in a variety of plants. In the present study, the effects of vanillin and 4HBA were first investigated on cell proliferation, as well as neuronal differentiation and integration of granule cells in the dentate gyrus (DG) of adolescent mice using Ki67, doublecortin (DCX) immunohistochemistry and 5bromo2'deoxyuridine (BrdU)/feminizing Locus on X 3 (NeuN) double immunofluorescence. In both the vanillin and 4HBA groups, the number of Ki67+ cells, DCX+ neuroblasts and BrdU+/NeuN+ neurons were significantly increased in the subgranular zone of the DG, as compared with the vehicle group. In addition, the levels of brainderived neurotrophic factor (BDNF) and tropomyosinrelated kinase B (TrkB), a BDNF receptor, were significantly increased in the DG in the vanillin and 4HBA groups compared with the vehicle group. These results indicated that vanillin and 4HBA enhanced cell proliferation, neuroblast differentiation and integration of granule cells in the DG of adolescent mice . These neurogenic effects of vanillin and 4HBA may be closely associated with increases in BDNF and TrkB.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzaldehydes
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Benzyl Alcohols
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Cell Differentiation
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Dentate Gyrus
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Brain-Derived Neurotrophic Factor
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Neural Stem Cells
Limits:
Animals
Language:
En
Journal:
Mol Med Rep
Year:
2016
Document type:
Article