Poly (γ-glutamic acid)/beta-TCP nanocomposites via in situ copolymerization: Preparation and characterization.
J Biomater Appl
; 31(1): 102-11, 2016 07.
Article
in En
| MEDLINE
| ID: mdl-26945810
ABSTRACT
A series biodegradable poly (γ-glutamic acid)/beta-tricalcium phosphate (γ-PGA/TCP) nanocomposites were prepared which were composed of poly-γ-glutamic acid polymerized in situ with ß-tricalcium phosphate and physiochemically characterized as bone graft substitutes. The particle size via dynamic light scattering, the direct morphological characterization via transmission electron microscopy and field emission scanning electron microscope, which showed that γ-PGA and ß-TCP were combined compactly at 80â, and the γ-PGA/TCP nanocomposites had homogenous and nano-sized grains with narrow particle size distributions. The water uptake and retention abilities, in vitro degradation properties, cytotoxicity in the simulated medium, and protein release of these novel γ-PGA/TCP composites were investigated. Cell proliferation in composites was nearly twice than ß-TCP when checked in vitro using MC3T3 cell line. We also envision the potential use of γ-PGA/TCP systems in bone growth factor or orthopedic drug delivery applications in future bone tissue engineering applications. These observations suggest that the γ-PGA/TCP are novel nanocomposites with great potential for application in the field of bone tissue engineering.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyglutamic Acid
/
Calcium Phosphates
/
Bone Substitutes
/
Delayed-Action Preparations
/
Nanocapsules
/
Nanocomposites
Limits:
Animals
Language:
En
Journal:
J Biomater Appl
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2016
Document type:
Article
Affiliation country:
China