Cost-effectiveness of two interventions for the prevention of postpartum hemorrhage in Senegal.
Int J Gynaecol Obstet
; 133(3): 307-11, 2016 Jun.
Article
in En
| MEDLINE
| ID: mdl-26952348
ABSTRACT
OBJECTIVE:
To compare, at the community level, the cost-effectiveness of oxytocin and misoprostol for the prevention of postpartum hemorrhage (PPH).METHODS:
The present cost-effectiveness study used data collected during a randomized trial that compared the prophylactic effectiveness of misoprostol and oxytocin for the prevention of PPH in a rural setting in Senegal between June 6 and September 21 2013. The two interventions were compared, with referral to a higher level facility owing to PPH being the outcome measure. The costs and effects were calculated for two hypothetical cohorts of patients delivering during a 1-year period, with each cohort receiving one intervention. A comparison with a third hypothetical cohort receiving the current standard of care was included. A sensitivity analysis was performed to estimate the impact of variations in model assumptions.RESULTS:
The cost per PPH referral averted was US$ 38.96 for misoprostol and US$ 119.15 for oxytocin. In all the scenarios modeled the misoprostol intervention dominated, except in the worst-case scenario, where the oxytocin intervention demonstrated slightly better cost-effectiveness.CONCLUSION:
The use of misoprostol for PPH prophylaxis could be cost effective and improve maternal outcomes in low-income settings.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxytocics
/
Oxytocin
/
Misoprostol
/
Postpartum Hemorrhage
Type of study:
Clinical_trials
/
Health_economic_evaluation
Limits:
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Africa
Language:
En
Journal:
Int J Gynaecol Obstet
Year:
2016
Document type:
Article