Long-Term Neurodevelopmental Outcome after Doxapram for Apnea of Prematurity.
Neonatology
; 110(1): 21-6, 2016.
Article
in En
| MEDLINE
| ID: mdl-26967910
ABSTRACT
BACKGROUND:
Doxapram has been advocated as a treatment for persistent apnea of prematurity (AOP).OBJECTIVE:
To evaluate the effect of doxapram on long-term neurodevelopmental outcome in preterm infants as its safety still needs to be established.METHODS:
From a retrospective cohort of preterm infants with a gestational age (GA) <30 weeks and/or a birth weight <1,250 g, born between 2000 and 2010, infants treated with doxapram (n = 142) and a nontreated control group were selected (n = 284). Patient characteristics and clinical and neurodevelopmental outcome data at 24 months' corrected age were collected. Neurodevelopmental delay (ND) was defined as having a Mental or Psychomotor Developmental Index (MDI/PDI) <-1 standard deviation (SD), cerebral palsy, or a hearing or visual impairment. Odds ratios (OR) were calculated using multiple logistic regression analyses adjusting for potential confounders.RESULTS:
Infants treated with doxapram had a lower GA compared to controls. The number of infants with a MDI or PDI <-1 SD was not different between the groups. The risk of the combined outcome death or ND was significantly lower in the doxapram group after adjusting for confounding factors (OR = 0.54, 95% CI 0.37, 0.78). Doxapram-treated infants had a higher risk of bronchopulmonary dysplasia and patent ductus arteriosus, but a lower risk of spontaneous intestinal perforation. All other morbidities were not different between the groups.CONCLUSIONS:
This study suggests that doxapram is not associated with an increased risk of ND. These findings need to be confirmed or refuted by a large, well-designed, placebo-controlled randomized trial.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apnea
/
Doxapram
/
Central Nervous System Stimulants
/
Infant, Premature, Diseases
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Female
/
Humans
/
Infant
/
Male
/
Newborn
Country/Region as subject:
Europa
Language:
En
Journal:
Neonatology
Journal subject:
PERINATOLOGIA
Year:
2016
Document type:
Article
Affiliation country:
Netherlands