Optimized methods for preparation of 6(I)-(ω-sulfanyl-alkylene-sulfanyl)-ß-cyclodextrin derivatives.
Beilstein J Org Chem
; 12: 349-52, 2016.
Article
in En
| MEDLINE
| ID: mdl-26977195
ABSTRACT
A general high-yielding method for the preparation of monosubstituted ß-cyclodextrin derivatives which have attached a thiol group in position 6 is described. The thiol group is attached through linkers of different lengths and repeating units (ethylene glycol or methylene). The target compounds were characterized by IR, MS and NMR spectra. A simple method for their complete conversion to the corresponding disulfides as well as a method for the reduction of the disulfides back to the thiols is presented. Both, thiols and disulfides are derivatives usable for well-defined covalent attachment of cyclodextrin to gold or polydopamine-coated solid surfaces.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Beilstein J Org Chem
Year:
2016
Document type:
Article
Affiliation country:
Czech Republic