(1)H, (13)C and (15)N resonance assignments of the Cdc42-binding domain of TOCA1.
Biomol NMR Assign
; 10(2): 407-11, 2016 10.
Article
in En
| MEDLINE
| ID: mdl-26988723
ABSTRACT
TOCA1 is a downstream effector protein of the small GTPase, Cdc42. It is a multi-domain protein that includes a membrane binding F-BAR domain, a homology region 1 (HR1) domain, which binds selectively to active Cdc42 and an SH3 domain. TOCA1 is involved in the regulation of actin dynamics in processes such as endocytosis, filopodia formation, neurite elongation, cell motility and invasion. Structural insight into the interaction between TOCA1 and Cdc42 will contribute to our understanding of the role of TOCA1 in actin dynamics. The (1)H, (15)N and (13)C NMR backbone and sidechain resonance assignment of the HR1 domain (12 kDa) presented here provides the foundation for structural studies of the domain and its interactions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carrier Proteins
/
Nuclear Magnetic Resonance, Biomolecular
/
Cdc42 GTP-Binding Protein
/
Xenopus Proteins
Limits:
Animals
Language:
En
Journal:
Biomol NMR Assign
Journal subject:
BIOLOGIA MOLECULAR
/
MEDICINA NUCLEAR
Year:
2016
Document type:
Article
Affiliation country:
United kingdom