Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma mansoni.
Chembiochem
; 17(11): 1004-7, 2016 06 02.
Article
in En
| MEDLINE
| ID: mdl-26991635
ABSTRACT
An organometallic derivative of praziquantel was studied directly in worms by using inductively coupled plasma-mass spectrometry (ICP-MS) for quantification and synchrotron-based imaging. X-ray fluorescence (XRF) and IR absorption spectromicroscopy were used for the first time in combination to directly locate this organometallic drug candidate in schistosomes. The detection of both CO (IR) and Cr (XRF) signatures proved that the Cr(CO)3 core remained intact in the worms. Images showed a preferential accumulation at the worm's tegument, consistent with a possible targeting of the calcium channel but not excluding other biological targets inside the worm.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Praziquantel
/
Schistosoma mansoni
Limits:
Animals
Language:
En
Journal:
Chembiochem
Journal subject:
BIOQUIMICA
Year:
2016
Document type:
Article
Affiliation country:
France