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Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma mansoni.
Clède, Sylvain; Cowan, Noemi; Lambert, François; Bertrand, Hélène C; Rubbiani, Riccardo; Patra, Malay; Hess, Jeannine; Sandt, Christophe; Trcera, Nicolas; Gasser, Gilles; Keiser, Jennifer; Policar, Clotilde.
Affiliation
  • Clède S; École Normale Supérieure, PSL Research University, Département de Chimie, 24 rue Lhomond, 75005, Paris, France.
  • Cowan N; Sorbonne Universités, UPMC Univ Paris 06, LBM, 4 place Jussieu, 75005, Paris, France.
  • Lambert F; Centre National de la Recherche Scientifique (CNRS), UMR 7203 LBM, 75005, Paris, France.
  • Bertrand HC; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute Basel, Switzerland, University of Basel, P. O. Box, 4003, Basel, Switzerland.
  • Rubbiani R; École Normale Supérieure, PSL Research University, Département de Chimie, 24 rue Lhomond, 75005, Paris, France.
  • Patra M; Sorbonne Universités, UPMC Univ Paris 06, LBM, 4 place Jussieu, 75005, Paris, France.
  • Hess J; Centre National de la Recherche Scientifique (CNRS), UMR 7203 LBM, 75005, Paris, France.
  • Sandt C; École Normale Supérieure, PSL Research University, Département de Chimie, 24 rue Lhomond, 75005, Paris, France.
  • Trcera N; Sorbonne Universités, UPMC Univ Paris 06, LBM, 4 place Jussieu, 75005, Paris, France.
  • Gasser G; Centre National de la Recherche Scientifique (CNRS), UMR 7203 LBM, 75005, Paris, France.
  • Keiser J; Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
  • Policar C; Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
Chembiochem ; 17(11): 1004-7, 2016 06 02.
Article in En | MEDLINE | ID: mdl-26991635
ABSTRACT
An organometallic derivative of praziquantel was studied directly in worms by using inductively coupled plasma-mass spectrometry (ICP-MS) for quantification and synchrotron-based imaging. X-ray fluorescence (XRF) and IR absorption spectromicroscopy were used for the first time in combination to directly locate this organometallic drug candidate in schistosomes. The detection of both CO (IR) and Cr (XRF) signatures proved that the Cr(CO)3 core remained intact in the worms. Images showed a preferential accumulation at the worm's tegument, consistent with a possible targeting of the calcium channel but not excluding other biological targets inside the worm.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Praziquantel / Schistosoma mansoni Limits: Animals Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2016 Document type: Article Affiliation country: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Praziquantel / Schistosoma mansoni Limits: Animals Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2016 Document type: Article Affiliation country: France